Drug Markup About Cheaper Meds Pharma & Politics See the Markups

💊

Drug Markup Database

Search our database to see how much pharmaceutical companies really spend to make the pills you’re paying hundreds for — and how much they’re charging you instead.

Humira

2,900% 🔥

Adalimumab

Rheumatoid arthritis

Manufacturing Cost:$200

U.S. Retail Price:$6,000

🌐 International Prices

🇩🇪 Germany: $2,041
🇬🇧 UK: $2,222
🇮🇳 India: $360
🇨🇦 Canada: $2,620

Keytruda

2,000% 🔥

Pembrolizumab

Cancer (melanoma, lung)

Manufacturing Cost:$500

U.S. Retail Price:$10,500

🌐 International Prices

🇩🇪 Germany: $3,571
🇬🇧 UK: $3,889
🇮🇳 India: $630
🇨🇦 Canada: $4,585

Eliquis

36,567% 🔥

Apixaban

Atrial fibrillation (anticoagulation)

Manufacturing Cost:$2

U.S. Retail Price:$550

🌐 International Prices

🇩🇪 Germany: $187
🇬🇧 UK: $204
🇮🇳 India: $33
🇨🇦 Canada: $240

Revlimid

1,850% 🔥

Lenalidomide

Multiple myeloma

Manufacturing Cost:$400

U.S. Retail Price:$7,800

🌐 International Prices

🇩🇪 Germany: $2,653
🇬🇧 UK: $2,889
🇮🇳 India: $468
🇨🇦 Canada: $3,406

Opdivo

2,033% 🔥

Nivolumab

Cancer (melanoma, lung)

Manufacturing Cost:$450

U.S. Retail Price:$9,600

🌐 International Prices

🇩🇪 Germany: $3,265
🇬🇧 UK: $3,556
🇮🇳 India: $576
🇨🇦 Canada: $4,192

Imbruvica

2,058% 🔥

Ibrutinib

CLL / B‑cell cancers

Manufacturing Cost:$380

U.S. Retail Price:$8,200

🌐 International Prices

🇩🇪 Germany: $2,789
🇬🇧 UK: $3,037
🇮🇳 India: $492
🇨🇦 Canada: $3,581

Trulicity

42,400% 🔥

Dulaglutide

Type 2 diabetes

Manufacturing Cost:$2

U.S. Retail Price:$850

🌐 International Prices

🇩🇪 Germany: $289
🇬🇧 UK: $315
🇮🇳 India: $51
🇨🇦 Canada: $371

Stelara

3,513% 🔥

Ustekinumab

Plaque psoriasis

Manufacturing Cost:$310

U.S. Retail Price:$11,200

🌐 International Prices

🇩🇪 Germany: $3,810
🇬🇧 UK: $4,148
🇮🇳 India: $672
🇨🇦 Canada: $4,891

Ibrance

3,186% 🔥

Palbociclib

HR+ breast cancer

Manufacturing Cost:$280

U.S. Retail Price:$9,200

🌐 International Prices

🇩🇪 Germany: $3,129
🇬🇧 UK: $3,407
🇮🇳 India: $552
🇨🇦 Canada: $4,018

Enbrel

2,678% 🔥

Etanercept

Rheumatoid arthritis

Manufacturing Cost:$270

U.S. Retail Price:$7,500

🌐 International Prices

🇩🇪 Germany: $2,551
🇬🇧 UK: $2,778
🇮🇳 India: $450
🇨🇦 Canada: $3,275

Ozempic

29,900% 🔥

Semaglutide

Type 2 diabetes

Manufacturing Cost:$3

U.S. Retail Price:$900

🌐 International Prices

🇩🇪 Germany: $306
🇬🇧 UK: $333
🇮🇳 India: $54
🇨🇦 Canada: $393

Xarelto

27,678% 🔥

Rivaroxaban

Atrial fibrillation (anticoagulation)

Manufacturing Cost:$2

U.S. Retail Price:$500

🌐 International Prices

🇩🇪 Germany: $170
🇬🇧 UK: $185
🇮🇳 India: $30
🇨🇦 Canada: $218

Dupixent

29,900% 🔥

Dupilumab

Atopic dermatitis

Manufacturing Cost:$4

U.S. Retail Price:$1,200

🌐 International Prices

🇩🇪 Germany: $408
🇬🇧 UK: $444
🇮🇳 India: $72
🇨🇦 Canada: $524

Januvia

26,371% 🔥

Sitagliptin

Type 2 diabetes

Manufacturing Cost:$2

U.S. Retail Price:$450

🌐 International Prices

🇩🇪 Germany: $153
🇬🇧 UK: $167
🇮🇳 India: $27
🇨🇦 Canada: $196

Jardiance

33,233% 🔥

Empagliflozin

Type 2 diabetes

Manufacturing Cost:$2

U.S. Retail Price:$500

🌐 International Prices

🇩🇪 Germany: $170
🇬🇧 UK: $185
🇮🇳 India: $30
🇨🇦 Canada: $218

Rybelsus

30,456% 🔥

Semaglutide (oral)

Type 2 diabetes

Manufacturing Cost:$2

U.S. Retail Price:$550

🌐 International Prices

🇩🇪 Germany: $187
🇬🇧 UK: $204
🇮🇳 India: $33
🇨🇦 Canada: $240

Tecfidera

33,500% 🔥

Dimethyl fumarate

Relapsing multiple sclerosis

Manufacturing Cost:$25

U.S. Retail Price:$8,400

🌐 International Prices

🇩🇪 Germany: $2,857
🇬🇧 UK: $3,111
🇮🇳 India: $504
🇨🇦 Canada: $3,668

Cosentyx

2,043% 🔥

Secukinumab

Plaque psoriasis

Manufacturing Cost:$350

U.S. Retail Price:$7,500

🌐 International Prices

🇩🇪 Germany: $2,551
🇬🇧 UK: $2,778
🇮🇳 India: $450
🇨🇦 Canada: $3,275

Xtandi

2,150% 🔥

Enzalutamide

Prostate cancer

Manufacturing Cost:$320

U.S. Retail Price:$7,200

🌐 International Prices

🇩🇪 Germany: $2,449
🇬🇧 UK: $2,667
🇮🇳 India: $432
🇨🇦 Canada: $3,144

Tagrisso

2,350% 🔥

Osimertinib

EGFR‑mutated NSCLC

Manufacturing Cost:$400

U.S. Retail Price:$9,800

🌐 International Prices

🇩🇪 Germany: $3,333
🇬🇧 UK: $3,630
🇮🇳 India: $588
🇨🇦 Canada: $4,280

Farxiga

23,900% 🔥

Dapagliflozin

Type 2 diabetes

Manufacturing Cost:$2

U.S. Retail Price:$600

🌐 International Prices

🇩🇪 Germany: $204
🇬🇧 UK: $222
🇮🇳 India: $36
🇨🇦 Canada: $262

Entresto

1,033% 🔥

Sacubitril/valsartan

Heart failure (HFrEF)

Manufacturing Cost:$150

U.S. Retail Price:$1,700

🌐 International Prices

🇩🇪 Germany: $578
🇬🇧 UK: $630
🇮🇳 India: $102
🇨🇦 Canada: $742

Tremfya

1,991% 🔥

Guselkumab

Plaque psoriasis

Manufacturing Cost:$330

U.S. Retail Price:$6,900

🌐 International Prices

🇩🇪 Germany: $2,347
🇬🇧 UK: $2,556
🇮🇳 India: $414
🇨🇦 Canada: $3,013

Skyrizi

1,988% 🔥

Risankizumab

Plaque psoriasis

Manufacturing Cost:$340

U.S. Retail Price:$7,100

🌐 International Prices

🇩🇪 Germany: $2,415
🇬🇧 UK: $2,630
🇮🇳 India: $426
🇨🇦 Canada: $3,100

Symbicort

33,233% 🔥

Budesonide/formoterol

Asthma / COPD

Manufacturing Cost:$1

U.S. Retail Price:$300

🌐 International Prices

🇩🇪 Germany: $102
🇬🇧 UK: $111
🇮🇳 India: $18
🇨🇦 Canada: $131

Zolgensma

123,429% 🔥

Onasemnogene abeparvovec

Spinal muscular atrophy

Manufacturing Cost:$1,700

U.S. Retail Price:$2,100,000

🌐 International Prices

🇩🇪 Germany: $714,286
🇬🇧 UK: $777,778
🇮🇳 India: $126,000
🇨🇦 Canada: $917,031

Biktarvy

52,757% 🔥

Bictegravir/emtricitabine/TAF

HIV‑1 infection

Manufacturing Cost:$7

U.S. Retail Price:$3,700

🌐 International Prices

🇩🇪 Germany: $1,258
🇬🇧 UK: $1,370
🇮🇳 India: $222
🇨🇦 Canada: $1,616

Gilenya

3,900% 🔥

Fingolimod

Relapsing multiple sclerosis

Manufacturing Cost:$200

U.S. Retail Price:$8,000

🌐 International Prices

🇩🇪 Germany: $2,721
🇬🇧 UK: $2,963
🇮🇳 India: $480
🇨🇦 Canada: $3,493

Victoza

33,233% 🔥

Liraglutide

Type 2 diabetes

Manufacturing Cost:$2

U.S. Retail Price:$800

🌐 International Prices

🇩🇪 Germany: $272
🇬🇧 UK: $296
🇮🇳 India: $48
🇨🇦 Canada: $349

Taltz

2,021% 🔥

Ixekizumab

Plaque psoriasis

Manufacturing Cost:$330

U.S. Retail Price:$7,000

🌐 International Prices

🇩🇪 Germany: $2,381
🇬🇧 UK: $2,593
🇮🇳 India: $420
🇨🇦 Canada: $3,057

Darzalex

3,604% 🔥

Daratumumab

Multiple myeloma

Manufacturing Cost:$270

U.S. Retail Price:$10,000

🌐 International Prices

🇩🇪 Germany: $3,401
🇬🇧 UK: $3,704
🇮🇳 India: $600
🇨🇦 Canada: $4,367

Aimovig

838%

Erenumab

Migraine prevention

Manufacturing Cost:$80

U.S. Retail Price:$750

🌐 International Prices

🇩🇪 Germany: $255
🇬🇧 UK: $278
🇮🇳 India: $45
🇨🇦 Canada: $328

Pomalyst

3,167% 🔥

Pomalidomide

Multiple myeloma

Manufacturing Cost:$300

U.S. Retail Price:$9,800

🌐 International Prices

🇩🇪 Germany: $3,333
🇬🇧 UK: $3,630
🇮🇳 India: $588
🇨🇦 Canada: $4,280

Evrysdi

3,740% 🔥

Risdiplam

Spinal muscular atrophy

Manufacturing Cost:$250

U.S. Retail Price:$9,600

🌐 International Prices

🇩🇪 Germany: $3,265
🇬🇧 UK: $3,556
🇮🇳 India: $576
🇨🇦 Canada: $4,192

Ocrevus

3,746% 🔥

Ocrelizumab

Multiple sclerosis

Manufacturing Cost:$260

U.S. Retail Price:$10,000

🌐 International Prices

🇩🇪 Germany: $3,401
🇬🇧 UK: $3,704
🇮🇳 India: $600
🇨🇦 Canada: $4,367

Kesimpta

3,141% 🔥

Ofatumumab (SC)

Multiple sclerosis

Manufacturing Cost:$290

U.S. Retail Price:$9,400

🌐 International Prices

🇩🇪 Germany: $3,197
🇬🇧 UK: $3,482
🇮🇳 India: $564
🇨🇦 Canada: $4,105

Kisqali

2,025% 🔥

Ribociclib

HR+ breast cancer

Manufacturing Cost:$400

U.S. Retail Price:$8,500

🌐 International Prices

🇩🇪 Germany: $2,891
🇬🇧 UK: $3,148
🇮🇳 India: $510
🇨🇦 Canada: $3,712

Orkambi

4,000% 🔥

Lumacaftor/ivacaftor

Cystic fibrosis (F508del)

Manufacturing Cost:$200

U.S. Retail Price:$8,200

🌐 International Prices

🇩🇪 Germany: $2,789
🇬🇧 UK: $3,037
🇮🇳 India: $492
🇨🇦 Canada: $3,581

Spinraza

175%

Nusinersen

Spinal muscular atrophy

Manufacturing Cost:$800

U.S. Retail Price:$2,200

🌐 International Prices

🇩🇪 Germany: $748
🇬🇧 UK: $815
🇮🇳 India: $132
🇨🇦 Canada: $961

Invega Sustenna

26,567% 🔥

Paliperidone palmitate

Schizophrenia

Manufacturing Cost:$4

U.S. Retail Price:$1,200

🌐 International Prices

🇩🇪 Germany: $408
🇬🇧 UK: $444
🇮🇳 India: $72
🇨🇦 Canada: $524

Spravato

2,071% 🔥

Esketamine

Treatment‑resistant depression

Manufacturing Cost:$350

U.S. Retail Price:$7,600

🌐 International Prices

🇩🇪 Germany: $2,585
🇬🇧 UK: $2,815
🇮🇳 India: $456
🇨🇦 Canada: $3,319

Vraylar

3,956% 🔥

Cariprazine

Schizophrenia / bipolar I

Manufacturing Cost:$180

U.S. Retail Price:$7,300

🌐 International Prices

🇩🇪 Germany: $2,483
🇬🇧 UK: $2,704
🇮🇳 India: $438
🇨🇦 Canada: $3,188

Xifaxan

44,900% 🔥

Rifaximin

IBS‑D / hepatic encephalopathy

Manufacturing Cost:$2

U.S. Retail Price:$900

🌐 International Prices

🇩🇪 Germany: $306
🇬🇧 UK: $333
🇮🇳 India: $54
🇨🇦 Canada: $393

Xeljanz

2,869% 🔥

Tofacitinib

Rheumatoid arthritis

Manufacturing Cost:$320

U.S. Retail Price:$9,500

🌐 International Prices

🇩🇪 Germany: $3,231
🇬🇧 UK: $3,518
🇮🇳 India: $570
🇨🇦 Canada: $4,148

Venclexta

31,329% 🔥

Venetoclax

CLL

Manufacturing Cost:$4

U.S. Retail Price:$1,100

🌐 International Prices

🇩🇪 Germany: $374
🇬🇧 UK: $407
🇮🇳 India: $66
🇨🇦 Canada: $480

Vyvanse

41,567% 🔥

Lisdexamfetamine

ADHD

Manufacturing Cost:$1

U.S. Retail Price:$250

🌐 International Prices

🇩🇪 Germany: $85
🇬🇧 UK: $93
🇮🇳 India: $15
🇨🇦 Canada: $109

Benlysta

3,525% 🔥

Belimumab

Systemic lupus erythematosus

Manufacturing Cost:$240

U.S. Retail Price:$8,700

🌐 International Prices

🇩🇪 Germany: $2,959
🇬🇧 UK: $3,222
🇮🇳 India: $522
🇨🇦 Canada: $3,799

Ultomiris

3,724% 🔥

Ravulizumab

Paroxysmal nocturnal haemoglobinuria

Manufacturing Cost:$170

U.S. Retail Price:$6,500

🌐 International Prices

🇩🇪 Germany: $2,211
🇬🇧 UK: $2,407
🇮🇳 India: $390
🇨🇦 Canada: $2,838

Cabometyx

2,032% 🔥

Cabozantinib

Renal cell carcinoma

Manufacturing Cost:$380

U.S. Retail Price:$8,100

🌐 International Prices

🇩🇪 Germany: $2,755
🇬🇧 UK: $3,000
🇮🇳 India: $486
🇨🇦 Canada: $3,537

Trodelvy

2,521% 🔥

Sacituzumab govitecan

Triple‑negative breast cancer

Manufacturing Cost:$290

U.S. Retail Price:$7,600

🌐 International Prices

🇩🇪 Germany: $2,585
🇬🇧 UK: $2,815
🇮🇳 India: $456
🇨🇦 Canada: $3,319

ⓘ

How is this legal?

Because the U.S. doesn’t regulate drug prices like other countries do. While countries like Germany, Canada, and the UK negotiate directly with pharmaceutical companies to set fair prices for their citizens, the U.S. allows companies to charge whatever they want — leaving patients to pay the price for corporate greed.